anti- PD-L1/CD274 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Mouse, Pig | | Tested Application | ELISA, WB, IHC,IF | | Delivery Time | 2 to 4 working days | | Clone ID | 6C11 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q9NZQ7 | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).? | | Immunogen | CD274 molecule | | Synonyms | B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1 | | Recommended dilution | WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500 | Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab06281(PD-L1/CD274 Antibody) at dilution of 1:50 . heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
 | human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab06281(PD-L1/CD274 Antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab06281 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- PD-L1/CD274 antibody.
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