anti- STAT3 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Mouse, Rat | | Tested Application | ELISA, WB, IHC, IF, IP | | Delivery Time | 2 to 4 working days | | Clone ID | 6A9 | | Isotype | IgG2a | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P40763 | | Gene ID | | | Calculated MW | 88 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3. | | Immunogen | signal transducer and activator of transcription 3(acute-phase response factor) | | Synonyms | Acute phase response factor, APRF, FLJ20882, HIES, STAT3 | | Recommended dilution | WB: 1:2000-1:20000; IP: 1:1000-1:10000; IHC: 1:50-1:500; IF: 1:50-1:500 | Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab08300(STAT3 Antibody) at dilution of 1:300
 | HeLa cells were subjected to SDS PAGE followed by western blot with FNab08300(STAT3 antibody) at dilution of 1:4000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab08300 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- STAT3 antibody.
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