anti- Alpha-1-Antitrypsin antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Rat | | Tested Application | ELISA, WB, IHC, IF | | Delivery Time | 2 to 4 working days | | Clone ID | 5B1 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P01009 | | Calculated MW | 50 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease. | | Immunogen | serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1 | | Synonyms | A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin | | Recommended dilution | WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000 | Immunohistochemistry of paraffin-embedded human liver using FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
 | HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00338 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- Alpha-1-Antitrypsin antibody.
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