| Объем | 100 мкл |
| Синонимы | MLKL, ring finger and WD repeat domain 3, RING finger protein 201, RNF201, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q6PCD5 |
| Иммуноген | Synthesized peptide derived from internal of human RFWD3. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.<br/><br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/>Matsuoka S., Science 316:1160-1166(2007).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Others |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from MCF-7 cells, using RFWD3 antibody.
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Наименование: RFWD3 Antibody.