PARK7 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | ONCOGENE DJ1, PARK7 AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 2, PARK7 GENE, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q99497 | | Иммуноген | Synthesized peptide derived from human DJ-1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.<br/><br/>Nobutaka Hattori, Hum. Mol. Genet., Jan 2005, 14: 71 - 84.<br/>Raymond H. Kim, PNAS, Apr 2005, 102: 5215 - 5220.<br/>Rina Bandopadhyay, Brain, Feb 2004, 127: 420 - 430.<br/>Nan Zhong, J. Biol. Chem., Jul 2006, 281: 20940 - 20948.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using DJ-1 antibody.
 | Immunofluorescence analysis of HeLa cells, using DJ-1 antibody.
 | Western blot analysis of extracts from HuvEc cells, using DJ-1 antibody.
 | Western blot analysis of extracts from HuvEc cells (Lane 2) and HepG2 cells (Lane 3), using DJ-1 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: PARK7 Antibody.