EP300/CREBBP AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CREB-binding protein, CREBBP E1A-associated protein p300, EP300, P300 transcription coactivator homolog, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q09472/Q92793 | | Иммуноген | Synthesized peptide derived from human P300/CBP. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.<br/><br/>Gerd A. Blobel, J. Leukoc. Biol., Apr 2002, 71: 545. <br/>Eric Kalkhoven, Hum. Mol. Genet., Feb 2003, 12: 441 - 450. <br/>Wei-fang Shen, Mol. Cell. Biol., Nov 2001, 21: 7509 - 7522. <br/>Frederick C. Nucifora, Science, Mar 2001, 291: 2423. <br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Metabolism,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO205 cells, using P300/CBP antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using P300/CBP antibody.
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Наименование: EP300/CREBBP Antibody.