Recombinant human Myelin basic protein

Relevance: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0,200 mM Imidazole
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Amino acid sequence of the encephalitogenic basic protein from human myelin." Carnegie P.R. Biochem. J. 123:57-67(1971) [PubMed: 4108501] [Abstract] Cited for: PROTEIN SEQUENCE (ISOFORM 5). [2] "Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant." Roth H.J., Kronquist K.E., Pretorius P.J., Crandall B.F., Campagnoni A.T. J. Neurosci. Res. 16:227-238(1986) [PubMed: 2427738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6). Tissue: Embryonic spinal cord. [3] "Identification of three forms of human myelin basic protein by cDNA cloning." Kamholz J., de Ferra F., Puckett C., Lazzarini R.A. Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986) [PubMed: 2425357] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5).
Alias: Myelin A1 protein,Myelin membrane encephalitogenic protein.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	200 мкг
	Кат. номер:	CSB-RP109974h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Myelin basic protein. Примечание: дополнительная информация (на английском языке).