Козьи поликлональные антитела к каспазе 3 (L-18)caspase-3 (L-18)
- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of caspase-3 p20 of human origin
- recommended for detection of caspase-3 p20 and p17 subunits and full-length procaspase-3 of mouse, rat and human origin by WB, IP, IF and ELISA; partially cross-reactive with caspase-7; also reactive with additional species, including equine, canine, bovine, porcine and feline
- blocking peptide, sc-1225 P
Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system. Информация для заказа| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-1225 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Козьи поликлональные антитела к каспазе 3 (L-18) / caspase-3 (L-18).
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, ELISA,
UNSPSC: 12352203,
datasheet |
|
