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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела

anti- WDR61 antibody

Спецификация

Clonalitypolyclonal
HostRabbit
SpecificityHuman, Mouse, Rat
Tested ApplicationELISA, WB, IHC, IF
Delivery Time2 to 4 working days
IsotypeIgG
Formliquid
PurificationImmunogen affinity purified
Purity≥95% as determined by SDS-PAGE
Uniprot IDQ9GZS3
Gene ID
Calculated MW122 kDa
Ссылка на страницу на сайте производителяссылка
ИнструкцияPDF
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BackgroundComponent of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'-and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4'(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono-and trimethylation on histone H3 'Lys-4'(H3K4me3), dimethylation on histone H3 'Lys-79'(H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
ImmunogenWD repeat domain 61
SynonymsREC14, SKI8, WD repeat domain 61, WDR61
Recommended dilutionWB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab09500(WDR61 Antibody) at dilution of 1:50
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab09500(WDR61 antibody) at dilution of 1:1000
  

Информация для заказа

Область использования:Производство:Fine Biotech
Метод:Антитела 
Объем:100µg 
Кат. номер:FNab09500
Цена (с НДС 20%):по запросуВ корзину
anti- WDR61 antibodyНаименование: anti- WDR61 antibody.
Примечание:
   
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info@LD.ru   тел.: +7 495 369-20-43