Phospho-NTRK1 (Tyr680/681) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth, TRK, Trk-A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04629 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.<br/><br/>Liu HY, et al. (2005) J Biol Chem 280, 19461-71 <br />Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51 <br />Marsh HN, et al. (2003) J Cell Biol 163, 999-1010</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr680/681 | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA095633 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-NTRK1 (Tyr680/681) Antibody.
Примечание: дополнительная информация (на английском языке). |
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