Объем | 50 мкг |
Синонимы | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X), UPF3B, RENT3B UPF3X |
Клональность | Polyclonal Antibody |
Организм | Human |
uniprot | Q9BZI7 |
Иммуноген | Recombinant Human Regulator of nonsense transcripts 3B protein (319-423AA) |
Источник | Rabbit |
Видовая специфичность | Human |
Применение | ELISA |
Примечание | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation, the function is independent of association with UPF2 and components of the EJC core. |
Клональность1 | Polyclonal |
Изотип | IgG |
Коньюгат | Biotin |
Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Форма | Liquid |
Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Метод очистки | >95%, Protein G purified |
Абревеатура | Regulator of nonsense transcripts 3B |
Области исследований | Epigenetics and Nuclear Signaling |
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