| Объем | 100 мкл |
| Синонимы | EAR2, ERBAL2, NR2F6, Orphan nuclear receptor EAR-2, V-erbA related protein EAR-2 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P10588 |
| Иммуноген | Synthesized peptide derived from N-terminal of human NR2F6. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Примечание | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock, is required early in the development of the locus coeruleus (LC).<br/><br/>Miyajima N., Nucleic Acids Res. 16:11057-11074(1988).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HeLa cells, 293 cells and HUVEC cells, using NR2F6 antibody.
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Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using NR2F6 antibody.
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Immunofluorescence analysis of HepG2 cells, using NR2F6 antibody.
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Наименование: NR2F6 Antibody.