ARHGAP17 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | NADRIN, neuron-associated developmentally regulated protein, RHG17, rho GTPase activating protein 17, RhoGAP interacting with CIP4 homologs 1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q68EM7 | | Иммуноген | Synthesized peptide derived from internal of humanRHG17. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.<br/><br/>Richnau N., J. Biol. Chem. 276:35060-35070(2001).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/>The German cDNA consortium, Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from LOVO cells, using RHG17 antibody.
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Наименование: ARHGAP17 Antibody.