Антитела PE anti-human LOX-1 Antibody PE anti-human LOX-1 Antibody
- Clone
- 15C4 (See other available formats)
- Other Names
- OLR1, LOX1, LOXIN, SLOX1, CLEC8A, SCARE1
- Isotype
- Mouse IgG2a, κ
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Description
Lectin-like oxidized LDL receptor 1 (LOX-1), also known as CLEC8A, is a 31 kD, single pass, type II, transmembrane protein, member of the C-type lectin superfamily. LOX-1 is a scavenger receptor involved in endocytosis, phagocytosis, and cytokine production. LOX-1 is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, and macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognized numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein, and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.
Product Details
Technical Data Sheet (pdf)
- Isotype Control
- PE Mouse IgG2a, κ Isotype Ctrl
- Reactivity
- Human
- Immunogen
- LOX-1 ectodomain:Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Concentration
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
- Application References
(PubMed link indicates BioLegend citation)
-
1. Li D, et al. 2012. J. Exp. Med. 209:109.
Publication Library
- RRID
- AB_2562180 (BioLegend Cat. No. 358603)
AB_2562181 (BioLegend Cat. No. 358604)
- Structure
- Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily
- Distribution
- Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; upregulated by inflammatory and oxidative stimuli
- Function
- Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
- Ligand Receptor
- Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, and oxidized LDL
- Antigen References
-
1. Yin Y, et al. 2013. Eur. J. Cell. Biol. 92:150.
2. Khaidakov M and Mehta JL, 2012. PLoS One. 7:e46973.
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439.
4. Lin FY, et al. 2011. J. Immunol. 186:4405.
5. Parlato S, et al. 2010. Blood 115:1554.
- Gene ID
- 4973 View all products for this Gene ID4973 View all products for this Gene ID
- UniProt
- View information about LOX-1 on UniProt.org
Информация для заказа| Область использования: | Производство: | Biolegend | | Метод: | | | Объем: | 100 tests | | Кат. номер: | 358604 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: Антитела PE anti-human LOX-1 Antibody / PE anti-human LOX-1 Antibody .
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