Recombinant human Vascular endothelial growth factor A protein

Relevance: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Product Info: His tagged
Source: E.coli derived
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Vascular endothelial growth factor is a secreted angiogenic mitogen." Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N. Science 246:1306-1309(1989) [PubMed: 2479986] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF189 AND VEGF165). [2] "Vascular permeability factor, an endothelial cell mitogen related to PDGF." Keck P.J., Hauser S.D., Krivi G., Sanzo K., Warren T., Feder J., Connolly D.T. Science 246:1309-1312(1989) [PubMed: 2479987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF189), PARTIAL PROTEIN SEQUENCE. [3] "The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing." Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J.C., Abraham J.A. J. Biol. Chem. 266:11947-11954(1991) [PubMed: 1711045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM VEGF189).
Alias: Vascular permeability factor,VPF.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	1 мг
	Кат. номер:	CSB-RP082474h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Vascular endothelial growth factor A protein. Примечание: дополнительная информация (на английском языке).