Recombinant human Superoxide dismutase [Cu-Zn] protein

Relevance: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
Product Info: GST-tagged
Source: E.coli derived
Purity: 95%
Image:
Tested applications: SDS-PAGE, ELISA, Western blot
Storage Buffer: PBS buffer,20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Referrences: [1] "Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA." Sherman L., Dafni N., Lieman-Hurwitz J., Groner Y. Proc. Natl. Acad. Sci. U.S.A. 80:5465-5469(1983) [PubMed: 6577438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] "Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase." Levanon D., Lieman-Hurwitz J., Dafni N., Wigderson M., Sherman L., Bernstein Y., Laver-Rudich Z., Danciger E., Stein O., Groner Y. EMBO J. 4:77-84(1985) [PubMed: 3160582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] "Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library." Hallewell R.A., Masiarz F.R., Najarian R.C., Puma J.P., Quiroga M.R., Randolph A., Sanchez-Pescador R., Scandella C.J., Smith B., Steimer K.S., Mullenbach G.T. Nucleic Acids Res. 13:2017-2034(1985) [PubMed: 3889846] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] "Comparison of properties between human recombinant and placental copper-zinc SOD." Kajihara J., Enomoto M., Nishijima K., Yabuuchi M., Katoh K. J. Biochem. 104:851-854(1988) [PubMed: 2853161] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Alias: Superoxide dismutase 1,hSod1.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	10 мкг
	Кат. номер:	CSB-RP028644h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Superoxide dismutase [Cu-Zn] protein. Примечание: дополнительная информация (на английском языке).