| Highlight | Pubmed/Publication |
| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Mouse, Rat, Rabbit, Sheep |
| Tested Application | ELISA, WB, IHC, IP, FC, IF |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q07812 |
| Gene ID | |
| Calculated MW | 21 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579). |
| Immunogen | BCL2-associated X protein |
| Synonyms | BCL2L4,Apoptosis regulator BAX, BAX |
| Recommended dilution | WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200; IF: 1:10-1:100 |
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab00810(BAX Antibody) at dilution of 1:50
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00810(BAX antibody) at dilution of 1:1000
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