Phospho-AKT1 (Ser129) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AKT, AKT1 kinase, kinase Akt1, RAC, RAC-PK-alpha | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P31749 | | Иммуноген | Peptide sequence around phosphorylation site of serine129(D-N-S(p)-G-A) derived from Human Akt . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. <br/><br/>Nguyen le XT, Mitchell BS (2013) Proc Natl Acad Sci U S A 110, 20681-6 <br />Ponce DP, et al. (2011) Mol Cell Biochem 356, 127-32 <br />Siddiqui-Jain A, et al. (2010) Cancer Res 70, 10288-98 </p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser129 | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from A549 cells treated with PMA using Phospho-Akt (Ser129) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA115404 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-AKT1 (Ser129) Antibody.
Примечание: дополнительная информация (на английском языке). |
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