Phospho-CHUK/IKBKB (Ser176/177) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FLJ40509, I-kappa-B kinase, IKBKB, kinase beta, NFKBIKB | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O15111/O14920 | | Иммуноген | Peptide sequence around phosphorylation site of serine 176/177 (Q-G-S(p)-L-C) derived from Human IKK-alpha/beta. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. <br/><br/>Chandrakesan P, et al. (2010)J Biol Chem 285, 33485-98<br />Hinz M, et al. (2010 Mol Cell 40, 63-74 <br />Choudhary S, Lu M, Cui R, Brasier AR (2007)Mol Endocrinol 21, 2203-17</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser176/177 | | Области исследований | Cancer,Cardiovascular,Cell biology,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from NIH-3T3 cells treated with TNF using IKK- alpha/ beta (Phospho-Ser176/177) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA983649 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-CHUK/IKBKB (Ser176/177) Antibody.
Примечание: дополнительная информация (на английском языке). |
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