FAS AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P25445 | | Иммуноген | Peptide sequence around aa.323~327 (E-N-S-N-F) derived from human Fas . | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). <br/><br/>Hahne, M. et al. (1995) Int Immunol 7, 1381-6.<br/>Nagata, S. (1997) Cell 88, 355-65.<br/>Green, D.R. and Ferguson, T.A. (2001) Nat Rev Mol Cell Biol 2, 917-24.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cell biology,Immunology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2, Hela and 293 cells using Fas Antibody.
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Наименование: FAS Antibody.