CASP10 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | ALPS2, CASP10B, FLICE2, Caspase 10 isoform a preproprotein, Caspase 10 isoform b preproprotein | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q92851 | | Иммуноген | Synthesized peptide derived from human Caspase 10. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.<br/><br/>Frank C. Kischkel, J. Biol. Chem., Nov 2001, 276: 46639 - 46646.<br/>Ingo H. Engels, Mol. Cell. Biol., Apr 2005, 25: 2808 - 2818.<br/>Daniela Sciaky, J. Immunol., Apr 2000, 164: 3806.<br/>Jin Wang, PNAS, Nov 2001, 98: 13884. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cell biology,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 10 antibody.
 | Immunofluorescence analysis of HeLa cells, using Caspase 10 antibody.
 | Western blot analysis of extracts from HeLa cells, using Caspase 10 antibody.
 | Western blot analysis of extracts from HeLa cells (Lane 2), using Caspase 10 antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: CASP10 Antibody.