| Объем | 100 мкл |
| Синонимы | AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P31749 |
| Иммуноген | Fusion protein corresponding to residues near the N terminal of human V-akt murine thymoma viral oncogene homolog 1 |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/15.
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Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using at dilution 1/15.
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Наименование: AKT1 Antibody.