HIF-1α Antibody (H-206) is a rabbit polyclonal IgG
- HIF-1α Antibody (H-206) is a rabbit polyclonal IgG provided at 200 µg/ml
- epitope corresponding to amino acids 575-780 mapping near the C-terminus of HIF-1α of human origin
- recommended for detection of HIF-1α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and bovine
- TransCruz reagent for Gel Supershift and ChIP applications, sc-10790 X, 200 µg/0.1 ml
- See 88 citations for HIF-1α Antibody (H-206)
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1å, HIF-1∫ (also designated Arnt 1), EPAS-1 (also designated HIF-2å) and HIF-3å, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1å is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1å dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1å independent. EPAS-1 and HIF-3å have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia. Информация для заказа| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-10790 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: HIF-1α Antibody (H-206) is a rabbit polyclonal IgG.
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, ELISA,
UNSPSC: 12352203,
datasheet |
|
