| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Rat |
| Tested Application | ELISA, WB, IP |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q13127 |
| Gene ID | |
| Calculated MW | 122 kDa, 200kd |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. |
| Immunogen | RE1-silencing transcription factor |
| Synonyms | NRSF, REST, X2 box repressor, XBR |
| Recommended dilution | WB: 1:500-1:1000; IP: 1:500-1:2000 |
HeLa cells were subjected to SDS PAGE followed by western blot with FNab07244(REST Antibody) at dilution of 1:1000
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Наименование: anti- REST antibody.