anti- YTHDF2 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human | | Tested Application | ELISA, WB, IF, IHC | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q9Y5A9 | | Gene ID | | | Calculated MW | 62 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103). | | Immunogen | YTH domain family, member 2 | | Synonyms | CLL associated antigen KW 14, HGRG8, NY REN 2, YTH domain family protein 2, YTH domain family, member 2, YTHDF2 | | Recommended dilution | WB: 1:500-1:5000; IF: 1:10-1:100; IP: 1:200-1:2000; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab09573(YTHDF2 Antibody) at dilution of 1:50
 | Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09573(YTHDF2 Antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab09573 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- YTHDF2 antibody.
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