| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Mouse |
| Tested Application | ELISA, WB, IHC, IF |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q8IZH2 |
| Gene ID | |
| Calculated MW | 192 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA(By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma(OGS). |
| Immunogen | 5'-3' exoribonuclease 1 |
| Synonyms | 5 3 exoribonuclease 1, 5' 3' exoribonuclease 1, DKFZp434P0721, DKFZp686B22225, DKFZp686F19113, FLJ41903, SEP1, XRN1 |
| Recommended dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
Immunohistochemistry of paraffin-embedded human heart slide using FNab09556(XRN1 Antibody) at dilution of 1:50
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab09556(XRN1 antibody) at dilution of 1:600
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