| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, WB, IHC, IF |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q96T88 |
| Gene ID | |
| Calculated MW | 110 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| Background | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. |
| Immunogen | ubiquitin-like with PHD and ring finger domains 1 |
| Synonyms | FLJ21925, hNP95, HuNp95, ICBP90, Nuclear protein 95, RING finger protein 106, RNF106, Transcription factor ICBP90, UHRF1 |
| Recommended dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50 |
Immunohistochemistry of paraffin-embedded human lung cancer using FNab09245(UHRF1 antibody) at dilution of 1:100
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab09245(UHRF1 antibody) at dilution of 1:1000
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