| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Mouse |
| Tested Application | ELISA, WB, IHC |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | O00308 |
| Gene ID | |
| Calculated MW | 95 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells(ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Immunogen | WW domain containing E3 ubiquitin protein ligase 2 |
| Synonyms | AIP2, WW domain containing protein 2, WWP2, WWp2 like |
| Recommended dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab09535(WWP2 antibody) at dilution of 1:100
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mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab09535(WWP2 antibody) at dilution of 1:500
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