| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Mouse |
| Tested Application | ELISA, IP, WB,IHC |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q9Y572 |
| Calculated MW | 57 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| Immunogen | receptor-interacting serine-threonine kinase 3 |
| Synonyms | Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3 |
| Recommended dilution | WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400 |
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab07312(RIP3 antibody) at dilution of 1:200
 |
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07312(RIP3 antibody) at dilution of 1:500
 |
| | |
