anti- SH2D1B antibody

Спецификация

Clonality	polyclonal
Host	Rabbit
Specificity	Human, Mouse, Rat
Tested Application	ELISA, WB, IHC
Delivery Time	2 to 4 working days
Isotype	IgG
Form	liquid
Purification	Immunogen affinity purified
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	O14796
Gene ID
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule(SLAM) family such as CD84, SLAMF1, LY9 and CD244(PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer(NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation(PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling(By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse(PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation(By similarity).
Immunogen	SH2 domain containing 1B
Synonyms	EAT2
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab07820(SH2D1B Antibody) at dilution of 1:200

Информация для заказа

Область использования: Поликлональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab07820
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- SH2D1B antibody. Примечание: