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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела

anti- RELB antibody

Спецификация

Clonalitypolyclonal
HostRabbit
SpecificityHuman
Tested ApplicationELISA, IF, IHC, IP, WB
Delivery Time2 to 4 working days
IsotypeIgG
Formliquid
PurificationImmunogen affinity purified
Purity≥95% as determined by SDS-PAGE
Uniprot IDQ01201
Gene ID
Ссылка на страницу на сайте производителяссылка
ИнструкцияPDF
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BackgroundNF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo-or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor(I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases(IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.
Immunogenv-rel reticuloendotheliosis viral oncogene homolog B
Recommended dilutionWB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab07234(RELB Antibody) at dilution of 1:50
Raji cells were subjected to SDS PAGE followed by western blot with FNab07234(RELB Antibody) at dilution of 1:1000
  

Информация для заказа

Область использования:Производство:Fine Biotech
Метод:Антитела 
Объем:100µg 
Кат. номер:FNab07234
Цена (с НДС 20%):по запросуВ корзину
anti- RELB antibodyНаименование: anti- RELB antibody.
Примечание:
   
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