| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Mouse, Rat |
| Tested Application | ELISA, WB, IHC, IP |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | P78560 |
| Calculated MW | 23 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | RAIDD, also named as CRADD, is an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1. It is a negative regulator of the CARMA1 signalosome and suppressor of Th1-and Th17-mediated inflammatory responses. |
| Immunogen | CASP2 and RIPK1 domain containing adaptor with death domain |
| Synonyms | CRADD, RAIDD |
| Recommended dilution | WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200 |
Immunohistochemistry of paraffin-embedded human colon cancer using FNab07092(CRADD antibody) at dilution of 1:100
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab07092(CRADD antibody) at dilution of 1:1000
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