Антитела к Anti-p21 (CDKN1A) кроличьи поликлональныеanti- P21;CDKN1A antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Mouse, Rat | | Tested Application | ELISA, IHC, IF, WB | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P38936 | | Calculated MW | 21 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | CDKN1A(p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or-CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. | | Immunogen | cyclin-dependent kinase inhibitor 1A(p21, Cip1) | | Synonyms | CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1 | | Recommended dilution | WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human kidney using FNab06067(P21 antibody) at dilution of 1:50
 | HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06067(P21 antibody) at dilution of 1:500
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab06067 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: Антитела к Anti-p21 (CDKN1A) кроличьи поликлональные / anti- P21;CDKN1A antibody.
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