anti- TREX1 antibody

Спецификация

Clonality	polyclonal
Host	Rabbit
Specificity	Human
Tested Application	ELISA, WB, IP
Delivery Time	2 to 4 working days
Isotype	IgG
Form	liquid
Purification	Immunogen affinity purified
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	Q9NSU2
Gene ID
Calculated MW	132 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA(ssDNA) and double-stranded DNA(dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA(ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Immunogen	three prime repair exonuclease 1
Synonyms	3 5 exonuclease TREX1, AGS1, AGS5, CRV, DKFZp434J0310, DNase III, DRN3, HERNS, TREX1
Recommended dilution	WB: 1:200-1:1000; IP: 1:200-1:1000
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08963(TREX1 Antibody) at dilution of 1:300

Информация для заказа

Область использования: Поликлональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab08963
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- TREX1 antibody. Примечание: