| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, IHC, WB |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q14676 |
| Gene ID | |
| Calculated MW | 270 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| Background | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. |
| Immunogen | mediator of DNA damage checkpoint 1 |
| Synonyms | KIAA0170, NFBD1 |
| Recommended dilution | WB: 1:500 - 1:2000; IHC: 1:100 - 1:200 |
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05072(MDC1 Antibody) at dilution of 1:100
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab05072(MDC1 antibody) at dilution of 1:1000
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