anti- IL33 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human | | Tested Application | ELISA, IHC, WB | | Delivery Time | 2 to 4 working days | | Clone ID | 4E8 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | O95760 | | Gene ID | | | Calculated MW | 35kd | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528).
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100). | | Immunogen | interleukin 33 | | Synonyms | C9orf26, IL1F11, NFHEV | | Recommended dilution | WB: 1:500-1:2000; IHC: 1:50-1:500 | Immunohistochemistry of paraffin-embedded human nasopharyngeal carcinoma tissue slide using FNab04272(IL33 Antibody) at dilution of 1:200
 | HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04272(IL33 Antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab04272 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- IL33 antibody.
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