anti- SNX5 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Mouse, Rat | | Tested Application | ELISA, WB, IHC, IP | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q9Y5X3 | | Gene ID | | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate(PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2)(PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin(Probable). Plays a role in the internalization of EGFR after EGF stimulation(Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent(PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles(ILVs) of the multivesicular body for subsequent lysosomal degradation(Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941). | | Immunogen | sorting nexin 5 | Immunohistochemistry of paraffin-embedded human kidney using FNab08094(SNX5 antibody) at dilution of 1:100
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab08094 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- SNX5 antibody.
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