anti- PCNA antibody

Спецификация

Clonality	monoclonal
Host	Mouse
Specificity	Human, Mouse
Tested Application	ELISA, WB, IHC, FC, IP
Delivery Time	2 to 4 working days
Clone ID	8F9
Isotype	IgG1
Form	liquid
Purification	Protein A+G purification
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	P12004
Gene ID
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic(AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response(DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways(PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion(TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Immunogen	proliferating cell nuclear antigen
Immunohistochemistry of paraffin-embedded human breast cancer using FNab06217(PCNA antibody) at dilution of 1:800
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06217(PCNA Antibody) at various dilution.

Информация для заказа

Область использования: Моноклональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab06217
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- PCNA antibody. Примечание: