anti- NCAM1/CD56 monoclonal antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Mouse | | Tested Application | ELISA, WB, IHC | | Delivery Time | 2 to 4 working days | | Clone ID | 0D10 | | Isotype | IgG2a | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P13591 | | Calculated MW | 140 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Neural cell adhesion molecule 1(NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin(Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA(PMID: 9696812). The glycosylphosphatidylinositol(GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats(FNIII). All three forms can be posttranslationally modified by addition of polysialic acid(PSA)(PMID: 14976519). Several other isofroms have also been described(PMID: 1856291). | | Immunogen | neural cell adhesion molecule 1 | | Synonyms | CD56, MSK39, N CAM 1, NCAM, NCAM 1, NCAM1 | | Recommended dilution | WB: 1:1000-1:10000; IHC: 1:200-1:1000 | Immunohistochemistry of paraffin-embedded human small cell lung carcinoma tissue slide using FNab05575(NCAM1 Antibody) at dilution of 1:800 Heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
 | fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab05575(NCAM1 Antibody) at dilution of 1:4000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab05575 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- NCAM1/CD56 monoclonal antibody.
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