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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела

anti- GPX4 antibody

Спецификация

Clonalitypolyclonal
HostRabbit
SpecificityHuman, Mouse, Rat
Tested ApplicationELISA, WB, IHC, IF
Delivery Time2 to 4 working days
IsotypeIgG
Formliquid
PurificationImmunogen affinity purified
Purity≥95% as determined by SDS-PAGE
Uniprot IDP36969
Gene ID
Calculated MW25 kDa
Ссылка на страницу на сайте производителяссылка
ИнструкцияPDF
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
BackgroundThe protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Immunogenglutathione peroxidase 4 (phospholipid hydroperoxidase)
Recommended dilutionWB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Immunohistochemistry of paraffin-embedded human liver injury using FNab03622(GPX4 antibody) at dilution of 1:50
mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab03622(GPX4 antibody) at dilution of 1:1000
  

Информация для заказа

Область использования:Производство:Fine Biotech
Метод:Антитела 
Объем:100µg 
Кат. номер:FNab03622
Цена (с НДС 20%):по запросуВ корзину
anti- GPX4 antibodyНаименование: anti- GPX4 antibody.
Примечание:
   
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info@LD.ru   тел.: +7 495 369-20-43