anti- CASP3 antibody

Спецификация

Clonality	monoclonal
Host	Mouse
Specificity	Human, Mouse, Rat
Tested Application	ELISA, IHC, WB,IF
Delivery Time	2 to 4 working days
Clone ID	2G7
Isotype	IgG1
Form	liquid
Purification	protein A+G purified
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	P42574
Gene ID
Calculated MW	32-35 kDa, 19 kDa, 17 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	0.01MPBS pH 7.4,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Immunogen	caspase 3, apoptosis-related cysteine peptidase
Synonyms	Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1
Recommended dilution	WB: 1:1000-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500
Immunohistochemistry of paraffin-embedded human breast cancer using FNab09938(CASP3 antibody) at dilution of 1:200
Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09938 (CASP3 antibody) at dilution of 1:3000

Информация для заказа

Область использования: Антитела CASP3 Моноклональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab09938
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- CASP3 antibody. Примечание: