anti- AMFR antibody

Спецификация

Clonality	polyclonal
Host	Rabbit
Specificity	Human, Mouse, Rat
Tested Application	ELISA, WB, IHC, IF, IP
Delivery Time	2 to 4 working days
Isotype	IgG
Form	liquid
Purification	Immunogen affinity purified
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	Q9UKV5
Gene ID
Calculated MW	73 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Immunogen	autocrine motility factor receptor
Synonyms	AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45
Recommended dilution	WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000
Immunohistochemistry of paraffin-embedded human ovary using FNab00358(AMFR antibody) at dilution of 1:100
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00358(AMFR antibody) at dilution of 1:800

Информация для заказа

Область использования: Поликлональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab00358
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- AMFR antibody. Примечание: