anti- ALK,CD246 antibodyСпецификация| Highlight | Pubmed/Publication | | Clonality | monoclonal | | Host | Mouse | | Specificity | Human | | Tested Application | ELISA, IHC, WB | | Delivery Time | 2 to 4 working days | | Clone ID | 2B10 | | Isotype | IgG2a | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q9UM73 | | Calculated MW | 176 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). The EML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570). | | Immunogen | anaplastic lymphoma receptor tyrosine kinase | | Synonyms | ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK | | Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human lymphoma slide using FNab00310(ALK,CD246 Antibody) at dilution of 1:50
 | Recombinant protein were subjected to SDS PAGE followed by western blot with FNab00310(ALK,CD246 Antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00310 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- ALK,CD246 antibody.
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