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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела

anti- ADARB1 antibody

Спецификация

Clonalitypolyclonal
HostRabbit
SpecificityHuman, Rat
Tested ApplicationELISA, WB
Delivery Time2 to 4 working days
IsotypeIgG
Formliquid
PurificationImmunogen affinity purified
Purity≥95% as determined by SDS-PAGE
Uniprot IDP78563
Gene ID
Calculated MW81 kDa
Ссылка на страницу на сайте производителяссылка
ИнструкцияPDF
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BackgroundCatalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA(dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites(hyper-editing) or at specific sites(site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein(BLCAP), neurotransmitter receptors for glutamate(GRIA2 and GRIK2) and serotonin(HTR2C), GABA receptor(GABRA3) and potassium voltage-gated channel(KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1(HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
Immunogenadenosine deaminase, RNA-specific, B1(RED1 homolog rat)
SynonymsADAR2, ADAR2a, ADAR2a L1, ADAR2a L2, ADAR2a L3, ADAR2b, ADAR2c, ADAR2d, ADAR2g, ADARB1, DRABA2, DRADA2, dsRNA adenosine deaminase, RED1, RNA editing deaminase 1, RNA editing enzyme 1
Recommended dilutionWB: 1:500-1:5000; IP: 1:500-1:5000
rat brain tissue were subjected to SDS PAGE followed by western blot with FNab00151(ADARB1 antibody) at dilution of 1:1000
  

Информация для заказа

Область использования:Производство:Fine Biotech
Метод:Антитела 
Объем:100µg 
Кат. номер:FNab00151
Цена (с НДС 20%):по запросуВ корзину
anti- ADARB1 antibodyНаименование: anti- ADARB1 antibody.
Примечание:
   
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