anti- ADARB1 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Rat | | Tested Application | ELISA, WB | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P78563 | | Gene ID | | | Calculated MW | 81 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA(dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites(hyper-editing) or at specific sites(site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein(BLCAP), neurotransmitter receptors for glutamate(GRIA2 and GRIK2) and serotonin(HTR2C), GABA receptor(GABRA3) and potassium voltage-gated channel(KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1(HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. | | Immunogen | adenosine deaminase, RNA-specific, B1(RED1 homolog rat) | | Synonyms | ADAR2, ADAR2a, ADAR2a L1, ADAR2a L2, ADAR2a L3, ADAR2b, ADAR2c, ADAR2d, ADAR2g, ADARB1, DRABA2, DRADA2, dsRNA adenosine deaminase, RED1, RNA editing deaminase 1, RNA editing enzyme 1 | | Recommended dilution | WB: 1:500-1:5000; IP: 1:500-1:5000 | rat brain tissue were subjected to SDS PAGE followed by western blot with FNab00151(ADARB1 antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00151 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: anti- ADARB1 antibody.
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