anti- ALKBH1 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Mouse, Rat | | Tested Application | ELISA, WB, IHC | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q13686 | | Gene ID | | | Calculated MW | 44 kDa, observed 44 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Dioxygenase that acts as a DNA demethylase(PubMed:18603530). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:18603530). Specifically demethylates DNA methylated on the 6th position of adenine(N(6)-methyladenosine) DNA. N(6)-methyladenosine(m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing(By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity(PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites(PubMed:19959401). DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product(PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation(By similarity). | | Immunogen | alkB, alkylation repair homolog 1(E. coli) | | Synonyms | ABH, ABH1, alkB, ALKBH, ALKBH1, DNA lyase ABH1, hABH | | Recommended dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab00311(ALKBH1 Antibody) at dilution of 1:50
 | human placenta tissue were subjected to SDS PAGE followed by western blot with FNab00311(ALKBH1 antibody) at dilution of 1:500
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00311 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- ALKBH1 antibody.
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