| Clonality | monoclonal |
| Host | Mouse |
| Specificity | Human, Rat |
| Tested Application | ELISA, WB, FC, IP, IHC |
| Delivery Time | 2 to 4 working days |
| Clone ID | 8A10 |
| Isotype | IgG2a |
| Form | liquid |
| Purification | Protein A+G purification |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | P10415 |
| Gene ID | |
| Calculated MW | 26 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). |
| Immunogen | B-cell CLL/lymphoma 2 |
| Synonyms | Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, Oncogene B cell leukemia 2 |
| Recommended dilution | WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000 |
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab00840(BCL2 Antibody) at dilution of 1:100
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U-937 cells were subjected to SDS PAGE followed by western blot with FNab00840(BCL2 Antibody) at dilution of 1:6000
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