| Объем | 100 мкл |
| Синонимы | KIAA0105, Putative pre-mRNA splicing regulator female-lethal (2D) homolog, WT1-associated protein, Wilms tumor 1-associating protein, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q15007 |
| Иммуноген | Synthesized peptide derived from C-terminal of human WTAP. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.<br/><br/>Ortega A., J. Biol. Chem. 278:3040-3047(2003).<br/>Nagase T., DNA Res. 2:37-43(1995).<br/>Mungall A.J., Nature 425:805-811(2003).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HUVEC cells, using WTAP antibody.
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Наименование: WTAP Antibody.