| Объем | 100 мкл |
| Синонимы | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P04637 |
| Иммуноген | Peptide sequence around aa. 44~48 (M-L-S-P-D) derived from Human p53. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.<br/><br/>Dhavan, R. and Tsai, L.H. (2001) Nat Rev Mol Cell Biol. 2: 749-759. <br/>Patrick, G. N. et al. (1998) J Biol Chem. 273: 24057-24064. <br/>Di Stefano V, et al. (2005) Oncogene. 24(35):5431-5442.<br/>Mayo LD, et al.(2005) J Biol Chem. 280(28):25953-25959.<br/>Wang L, et al. (2005) Oncogene. 24(18): 3020-3027.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HT29 cells using p53(Ab-46) Antibody.
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Наименование: TP53 (Ab-46) Antibody.