| Объем | 100 мкл |
| Синонимы | Tumor necrosis factor receptor superfamily member 11B [Precursor], Osteoprotegerin, Osteoclastogenesis inhibitory factor, TNFRSF11B, OCIF |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O00300 |
| Иммуноген | Synthesized peptide derived from Internal of human TR11B. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.<br/><br/>Simonet W.S., Cell 89:309-319(1997).<br/>Yasuda H., Endocrinology 139:1329-1337(1998).<br/>Morinaga T., Eur. J. Biochem. 254:685-691(1998).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cardiovascular,Immunology,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 cells, using TR11B antibody.
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Наименование: TNFRSF11B Antibody.