PTK2 (Ab-925) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FADK 1, FAK1, PTK2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05397 | | Иммуноген | Peptide sequence around aa.923~927 (K-V-Y-E-N) derived from Human FAK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 | | Примечание | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.<br/><br/>Sanders MA, et al. (2005) J Biol Chem, 280(25): 23516-22.<br/>Cherubini A, et al. (2005) Mol Biol Cell, 16(6): 2972-83.<br/>Toriumi Y, et al. (2003) FEBS Lett, 553(3): 419-22.<br/>Shi Q, et al. (2003) Mol Biol Cell, 14(10): 4306-15. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells using FAK(Ab-925) Antibody and the same antibody preincubated with blocking peptide.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FAK(Ab-925) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | Immunofluorescence staining of methanol-fixed Hela cells using FAK(Ab-925) Antibody.
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Наименование: PTK2 (Ab-925) Antibody.